|
| Status |
Public on Jul 13, 2021 |
| Title |
Blood-Tumor overlapping TCR repertoire predicts the clinical responses of PD-1 blockade in patients with gastrointestinal cancer [TCR-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
As the anti-PD-1 monoclonal antibody (mAb) becomes to be used in many types of cancers, the needs for the predictive biomarker of PD-1 blockade are growing. T cell receptor (TCR) repertoire—which reflects the anti-tumor T-cell responses based on the antigen specificity—is a potential biomarker of cancer immunotherapy. Here, we analyzed the TCR repertoire of patients with advanced gastrointestinal cancer and explored its association with clinical responses.
|
| |
|
| Overall design |
Eight patients with advanced gastrointestinal cancer were treated with an anti-PD-1 monoclonal antibody (nivolumab) every 3 weeks until disease progression. The TCR repertoire of the peripheral blood CD4+ and CD8+ T cells was analyzed once before and three times after the initiation of treatment, whereas in case of tumor biopsy it was analyzed before and after 6 weeks of initiation of the treatment.
|
| |
|
| Contributor(s) |
Aoki H, Ueha S, Nakamura Y, Shichino S, Nakajima H, Shimomura M, Sato A, Nakatsura T, Yoshino T, Matsushima K |
| Citation(s) |
34014607 |
| |
| Submission date |
Jul 16, 2020 |
| Last update date |
Aug 24, 2021 |
| Contact name |
Hiroyasu Aoki |
| E-mail(s) |
haoki-tky@rs.tus.ac.jp
|
| Phone |
08013746493
|
| Organization name |
Tokyo University of Science
|
| Department |
Research Institute for Biomedical Sciences
|
| Lab |
Division of Molecular Regulation of Inflammatory and Immune Diseases
|
| Street address |
2669 Yamazaki
|
| City |
Noda |
| State/province |
Chiba |
| ZIP/Postal code |
278-0022 |
| Country |
Japan |
| |
|
| Platforms (1) |
|
| Samples (77)
|
|
| This SubSeries is part of SuperSeries: |
| GSE154539 |
Blood-Tumor overlapping TCR repertoire predicts the clinical responses of PD-1 blockade in patients with gastrointestinal cancer |
|
| Relations |
| BioProject |
PRJNA646627 |
| SRA |
SRP272194 |
Less...
More...