|
| Status |
Public on Jan 01, 2021 |
| Title |
Single-cell RNA sequencing of golden hamster upper respiratory tract (nasal mucosa and trachea), lung, kidney and small intestine |
| Organism |
Mesocricetus auratus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Full understanding of the pathophysiology of COVID-19 is critical for adequate treatment and development of vaccine and therapeutics. Although Golden hamster has been emerged as animal model of COVID-19, it is unknown how SARS-CoV-2 enters and infects targeted epithelial cells at molecular and cellular levels. Here, by applying single cell RNA sequencing in the upper respiratory tract, lung, kidney and intestine of golden hamster, we show that the expression profiles of host factors for SARS-CoV-2 infection in specific cell types are similar to that of human.
These data can be applied to a larger investigation (data not provided here) into the expression patterns of host cell entry factors of SARS-CoV-2 in golden hamster organs.
|
| |
|
| Overall design |
To investigate the expression patterns of host cell entry factors of SARS-CoV-2 in golden hamster organs. Single cells from dedicated organs were isolated and single-cell transcriptome libraries were generated.
|
| |
|
| Contributor(s) |
Koh GY, Yang MJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 16, 2020 |
| Last update date |
Jan 04, 2021 |
| Contact name |
Myung Jin Yang |
| E-mail(s) |
mjyang@kaist.ac.kr
|
| Organization name |
Institute for Basic Science
|
| Street address |
34141
|
| City |
Daejeon |
| ZIP/Postal code |
34141 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL28882 |
HiSeq X Ten (Mesocricetus auratus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA646705 |
| SRA |
SRP272241 |
Less...
More...