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| Status |
Public on Apr 03, 2009 |
| Title |
Transcription profile of K-ras activated murine menstruating uteri |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The expression of K-ras transgene is induced in K-rasV12+/-/Cre+/+/ROSA26R-LacZ+/+ transgenic mice uteri, which were primed with hormone treatment. Decidualization was artificially induced in these uteri and hormone injection was withdrawn to induced menstruation-like endometrial degeneration. Microarray was then used to study the molecular changes in these menstruating uteri following the K-ras activation.
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| Overall design |
Uterine tissues were collected from K-ras induced and littermate controled menstruating uteri. Experiments were carried out using Illumina Mouse WG-6 BeadChips (n=6 in each group). Data were normalized in R environment using the Lumi Bioconductor package.
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| Contributor(s) |
Cheng C, Licence D, Luo F, Arends MJ, Print CC, Charncock-Jones DS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 02, 2009 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Ching-wen Cheng |
| E-mail(s) |
cwc28@cam.ac.uk
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| Phone |
01223-762321
|
| Organization name |
University of Cambridge
|
| Department |
Obstetrics and Gynaecology
|
| Street address |
Robinson Way
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 2SW |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL6568 |
Illumina mouse-6 v1.1 expression beadchips |
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| Samples (12)
|
| GSM388864 |
K-ras activated menstruating uterus 1 |
| GSM388865 |
K-ras activated menstruating uterus 2 |
| GSM388866 |
K-ras activated menstruating uterus 3 |
| GSM388867 |
K-ras activated menstruating uterus 4 |
| GSM388868 |
K-ras activated menstruating uterus 5 |
| GSM388869 |
K-ras activated menstruating uterus 6 |
| GSM388870 |
Littermate control menstruating uterus 1 |
| GSM388871 |
Littermate control menstruating uterus 2 |
| GSM388872 |
Littermate control menstruating uterus 3 |
| GSM388873 |
Littermate control menstruating uterus 4 |
| GSM388874 |
Littermate control menstruating uterus 5 |
| GSM388875 |
Littermate control menstruating uterus 6 |
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| Relations |
| BioProject |
PRJNA115687 |
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