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| Status |
Public on Oct 16, 2020 |
| Title |
Mouse transcriptome of two genetic mutations of Grm1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report two genetic mutations of GRM1, which are Grm1-S458A and Grm1b-R889W, identified from two natural short sleep families. The introduction of these mutations into mouse models also causes the mice to sleepless. Thus, these findings suggest GRM1 is another short sleep gene and highlight the essential roles of mGluRs in regulating human sleep.
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| |
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| Overall design |
Hippocampus transcriptome of four wildtype (WT) mice, four Grm1-S458A mice, and four Grm1b-R889W mice.
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| |
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| Contributor(s) |
Shi G, Xing L, Fan Z, Fu Y |
| Citation(s) |
33065013 |
| |
| Submission date |
Jul 28, 2020 |
| Last update date |
Jan 16, 2021 |
| Contact name |
Zenghua Fan |
| Organization name |
University of California, San Francisco
|
| Street address |
1550 4th Street
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA649166 |
| SRA |
SRP273931 |
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