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Series GSE155545 Query DataSets for GSE155545
Status Public on Dec 31, 2020
Title Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies showed that miR-199a is upregulated in pressure-overload cardiac hypertrophy and overexpression of miR-199a induces cardiac hypertrophy in vivo. However, the therapeutic role of anti-miR-199a treatment in cardiac hypertrophy is of little known. Here, we showed a novel and effective way to treat mice cardiac hypertrophy and restored cardiac function through injection of adeno-associated virus (AAV) which expressed anti-miR-199a tough decoys (TuDs). We performed the RNA-seq profiling in both AAV9-EGFP control and AAV9-anti-miR-199a TuDs injected cardiac hypertrophic mice. The transcriptome analysis indicates that genes related to cytoplasmic translation, mitochondrial respiratory chain complex assembly were upregulated by anti-miR-199a treated recovered hearts.
 
Overall design Examine expression of mRNAs in AAV9-EGFP and AAV9-anti-miR-199a tough decoys(TuDs) injected hypertrophic hearts
 
Contributor(s) Yan H, Li Y, Hua Y, Luo Y
Citation(s) 33473326
Submission date Aug 02, 2020
Last update date Jan 28, 2021
Contact name Hualin Yan
E-mail(s) hualin.yan@scu.edu.cn
Phone 86-82-85423193
Organization name West China Hospital, Sichuan University
Street address No.37, Guoxuexiang,
City Chengdu
State/province Sichuan
ZIP/Postal code 610041
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM4705979 Ctrl AAV9-EGFP replicate-1
GSM4705980 Ctrl AAV9-EGFP replicate-2
GSM4705981 Ctrl AAV9-EGFP replicate-3
Relations
BioProject PRJNA650214
SRA SRP275508

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE155545_all_gene_fpkm.txt.gz 2.5 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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