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| Status |
Public on May 06, 2021 |
| Title |
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report that loss of CCM3/PDCD10 in fibroblasts induces FAK/Src-paxillin signalling driving actomyosin-dependent mechanotransduction leading to YAP/TAZ signalling. In vivo, loss of CCM3 in fibroblasts drives excessive tissue remodelling leading to the dissemination of breast cancer cells to distant organs.
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| |
|
| Overall design |
Examination of the varying RNA levels in control human vulval cancer-associated fibroblasts versus CCM3-depleted cells
|
| |
|
| Contributor(s) |
Madsen CD, Wang S |
| Citation(s) |
34226698 |
| |
| Submission date |
Aug 04, 2020 |
| Last update date |
Jul 26, 2021 |
| Contact name |
Chris Denis Madsen |
| E-mail(s) |
chris.madsen@med.lu.se
|
| Organization name |
Lund University
|
| Department |
Laboratory Medicine
|
| Lab |
Cancer and Matrix Remodelling
|
| Street address |
Scheelevägen 2
|
| City |
Lund |
| ZIP/Postal code |
223 81 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA655226 |
| SRA |
SRP275829 |
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