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Series GSE155779 Query DataSets for GSE155779
Status Public on Nov 05, 2020
Title Genome-wide expression profiling of acute promyelocytic leukemia NB4 cells treated with all-trans-retinoic acid
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, therapy resistance, differentiation syndrome, and relapses require the development of new low-toxicity therapies based on the induction of blasts differentiation. Here, we performed a high-throughput gene expression profile of the maturation inducible APL cell line NB4 untreated or exposed to ATRA.
 
Overall design We performed a whole mRNA transcriptome analysis by Affymetrix microarray of NB4 cells exposed to 1 µM ATRA for 120h or only to DMSO as control (Ctrl). Two biological replicates were performed for each condition.
 
Contributor(s) Bianchi F, Di Masi A
Citation(s) 33167477
Submission date Aug 05, 2020
Last update date Feb 04, 2021
Contact name Fabrizio Bianchi
E-mail(s) f.bianchi@operapadrepio.it
Organization name Fondazione IRCCS Casa Sollievo della Sofferenza
Lab Cancer Biomarkers
Street address Viale Padre Pio 7
City San Giovanni Rotondo (FG)
State/province Outside U.S. & Canada
ZIP/Postal code 71013
Country Italy
 
Platforms (1)
GPL23159 [Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay)
Samples (4)
GSM4711993 NB4-DMSO-1
GSM4711994 NB4-DMSO-2
GSM4711995 NB4-ATRA-1
Relations
BioProject PRJNA655564

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE155779_RAW.tar 4.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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