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| Status |
Public on Sep 25, 2020 |
| Title |
SARS-CoV-2 infection induces transcriptomic alterations specific to activation of innate immunity and cellular distress. |
| Organism |
Mesocricetus auratus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In the grips of the 2019-2020 SARS-CoV-2 pandemic, the pathogenisis of the virus has been shown to induce sharp responses from the immune system of infected hosts and can result in severe/fatal pulmonary distress. To understand how the virus can provoke such responses in infected hosts we infected golden hamsters with validated SARS-CoV-2 clinical isolates from 5 patients to understand the dynamic changes and functionality of induced gene expression.
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| Overall design |
An analysis of the transcriptomic landscape induced by SARS-CoV-2 infection in a suitable live model .Lung tissue from SARS-CoV-2 infected hamsters was extracted and total RNA was collected for sequencing.
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| Web link |
https://www.biorxiv.org/content/10.1101/2020.08.28.271635v1
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| Contributor(s) |
Mok BW, Cremin C, Chen H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 10, 2020 |
| Last update date |
Jul 08, 2021 |
| Contact name |
Honglin Chen |
| E-mail(s) |
hlchen@hku.hk
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| Organization name |
The University of Hong Kong
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| Department |
Department of Microbiology
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| Lab |
State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine
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| Street address |
Rm 5-19, 5/F, Lab block, 21 Sassoon Road, Pokfulam
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| City |
Hong Kong |
| ZIP/Postal code |
0000 |
| Country |
Hong Kong |
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| Platforms (1) |
| GPL28997 |
Illumina NovaSeq 6000 (Mesocricetus auratus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA656299 |
| SRA |
SRP276957 |
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