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Series GSE15665 Query DataSets for GSE15665
Status Public on May 05, 2009
Title Using high-density exon arrays to profile gene expression in closely related species (HJAY)
Platform organism Homo sapiens
Sample organisms Macaca mulatta; Pan troglodytes; Homo sapiens
Experiment type Expression profiling by array
Summary Global comparisons of gene expression profiles between species provide significant insight into gene regulation, evolutionary processes, and disease mechanisms. In this work, we describe a flexible and intuitive approach for global expression profiling of closely related species, using high-density exon arrays designed for a single reference genome. The high-density probe coverage of exon arrays allows us to select the identical set of perfect-match probes for measuring expression levels of orthologous genes. This eliminates a serious confounding factor in probe affinity effects of species-specific microarray probes, and enables direct comparisons of estimated expression indexes across species.

Keywords: analysis of gene expression in tissues
 
Overall design We conducted Affymetrix Human Exon Junction array (HJAY array) profiling of RNAs from human, chimpanzee and rhesus macaque cerebellums, with three replicates per species.
 
Contributor(s) Xing Y
Citation(s) 19474342, 20864445
Submission date Apr 14, 2009
Last update date Nov 05, 2019
Contact name Yi Xing
E-mail(s) yi-xing@uiowa.edu
Phone 319-384-3099
Fax 319-384-3150
Organization name University of Iowa
Department Internal Medicine, Biomedical Engineering
Street address 3294 CBRB, 285 Newton Rd
City Iowa City
State/province IA
ZIP/Postal code 52242
Country USA
 
Platforms (1)
GPL8444 Affymetrix GeneChip Human HJAY Array 17K
Samples (9)
GSM392147 Human cerebellum, pooled, technical rep 1
GSM392148 Human cerebellum, pooled, technical rep 2
GSM392149 Human cerebellum, pooled, technical rep 3
This SubSeries is part of SuperSeries:
GSE15666 Using high-density exon arrays to profile gene expression in closely related species
Relations
BioProject PRJNA122927

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15665_RAW.tar 235.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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