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Status |
Public on Aug 28, 2020 |
Title |
Transcriptomic profiles of Pseudomonas aeruginosa PA14 grown in the presence or absence of mucins or mucin-glycans |
Organism |
Pseudomonas aeruginosa |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We use high-throughput sequencing to profile the response of the opportunistic mucosal pathogen Pseudomonas aeruginosa to mucins and mucin-glycans from the mucosal niche. We find that P. aeruginosa undergoes a genome-wide phenotypic shift in response to mucins and their attached glycans. Specifically, nearly all virulence pathways are downregulated in response to these host-produced factors. This study provides a framework for understanding how the host environment regulates bacterial function.
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Overall design |
Examination of differential gene expression in Pseudomonas aeruginosa in response to mucin and mucin sugars
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Contributor(s) |
Ribbeck K, Wheeler K, Wang B |
Citation(s) |
33125866 |
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Submission date |
Aug 27, 2020 |
Last update date |
Nov 27, 2020 |
Contact name |
Katharina Ribbeck |
E-mail(s) |
ribbeck@mit.edu
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Organization name |
Massachusetts Institute of Technology
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Department |
Biological Engineering
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Lab |
Ribbeck
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Street address |
21 Ames St
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City |
Cambridge |
State/province |
Massachusetts |
ZIP/Postal code |
02142 |
Country |
USA |
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Platforms (1) |
GPL18644 |
Illumina HiSeq 2000 (Pseudomonas aeruginosa) |
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Samples (14)
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Relations |
BioProject |
PRJNA659742 |
SRA |
SRP279065 |