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Status |
Public on Sep 04, 2020 |
Title |
RNA-seq of Runx3 cKO SFZ/DZ chondrocytes. |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Purpose: To demonstrate Runx3's association with organizing the extracellular matrix in SFZ/DZ chondrocytes. Method: RNA samples were collected from SFZ/DZ chondrocytes of 5-day-old Col2a1-Cre;Runx3fl/fl and Runx3fl/fl mice. Results: 18 genes were up- or down-regulated by more than 2-fold in the Runx3 knockout in SFZ. Conclusions: However, genes organizing the extracellular matrix were down-regulated in Runx3 cKO DZ chondrocytes.
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Overall design |
SFZ chondrocytes mRNA profiles of 5-day old Cntl and Runx3 cKO mice.
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Contributor(s) |
Nagata K, Saito T |
Citation(s) |
36261443 |
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Submission date |
Sep 03, 2020 |
Last update date |
Oct 31, 2022 |
Contact name |
Kosei Nagata |
E-mail(s) |
knagata-tky@umin.ac.jp
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Organization name |
the University of Tokyo
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Department |
Graduate School of Medicine
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Lab |
Sensory and Motor System Medicine
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Street address |
Hongo7-3-1
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City |
Bunkyo-ku |
State/province |
Tokyo |
ZIP/Postal code |
113-8655 |
Country |
Japan |
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Platforms (1) |
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Samples (12)
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Relations |
BioProject |
PRJNA661298 |
SRA |
SRP279990 |