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Series GSE15777 Query DataSets for GSE15777
Status Public on Apr 22, 2009
Title Spontaneous regression of chronic lymphocytic leukemia: clinical and biological features of 9 cases
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We describe 9 CLL patients who underwent a spontaneous clinical regression. CD38 and ZAP-70 were negative in all cases. Immunoglobulin heavy chain variable region (IgVH) genes, mutated in all 7 evaluable patients, were restricted to the VH3 family in 6, with the usage of VH3-30 gene in 2. The light chain variable region genes were mutated in 6/8 cases, with the usage of Vκ4-1 gene in 3. Microarray analysis of CLL cells revealed a distinctive genomic profile. The number of activated T lymphocytes expressing IFN-γ, TNF-α and IL-4 was similar between CLL in spontaneous regression and healthy individuals.
 
Overall design We compared gene expression profiles obtained from 4 cases of CLL who underwent spontaneous regression with that of 3 B-cells from healthy donors and 18 CLL cases with either stable or progressive disease.
 
Contributor(s) Del Giudice I, Chiaretti S, Tavolaro S, De Propris MS, Maggio R, Mancini F, Peragine N, Santangelo S, Marinelli M, Mauro FR, Guarini A, Foà R
Citation(s) 19387007
Submission date Apr 22, 2009
Last update date Dec 06, 2018
Contact name Sabina Chiaretti
E-mail(s) chiaretti@bce.uniroma1.it
Phone +3906441639824
Fax +390685795792
Organization name Division of Hematology
Department Cellular Technologies and Hematology
Street address Via Benevento, 6
City Rome
ZIP/Postal code 00161
Country Italy
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (25)
GSM396248 CLL stable disease (AECLL1)
GSM396249 CLL progressive disease (ARCLL2)
GSM396250 CLL progressive disease (CACLL3)
Relations
BioProject PRJNA116847

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15777_RAW.tar 80.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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