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Status |
Public on Apr 22, 2009 |
Title |
Spontaneous regression of chronic lymphocytic leukemia: clinical and biological features of 9 cases |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
We describe 9 CLL patients who underwent a spontaneous clinical regression. CD38 and ZAP-70 were negative in all cases. Immunoglobulin heavy chain variable region (IgVH) genes, mutated in all 7 evaluable patients, were restricted to the VH3 family in 6, with the usage of VH3-30 gene in 2. The light chain variable region genes were mutated in 6/8 cases, with the usage of Vκ4-1 gene in 3. Microarray analysis of CLL cells revealed a distinctive genomic profile. The number of activated T lymphocytes expressing IFN-γ, TNF-α and IL-4 was similar between CLL in spontaneous regression and healthy individuals.
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Overall design |
We compared gene expression profiles obtained from 4 cases of CLL who underwent spontaneous regression with that of 3 B-cells from healthy donors and 18 CLL cases with either stable or progressive disease.
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Contributor(s) |
Del Giudice I, Chiaretti S, Tavolaro S, De Propris MS, Maggio R, Mancini F, Peragine N, Santangelo S, Marinelli M, Mauro FR, Guarini A, Foà R |
Citation(s) |
19387007 |
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Submission date |
Apr 22, 2009 |
Last update date |
Dec 06, 2018 |
Contact name |
Sabina Chiaretti |
E-mail(s) |
chiaretti@bce.uniroma1.it
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Phone |
+3906441639824
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Fax |
+390685795792
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Organization name |
Division of Hematology
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Department |
Cellular Technologies and Hematology
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Street address |
Via Benevento, 6
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City |
Rome |
ZIP/Postal code |
00161 |
Country |
Italy |
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Platforms (1) |
GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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Samples (25)
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Relations |
BioProject |
PRJNA116847 |