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Series GSE158103 Query DataSets for GSE158103
Status Public on Sep 20, 2022
Title Targeting MDM2-induced p53 upregulation to enhance anti-leukemia immunity post allogeneic stem cell transplantation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Relapse after allo-HCT is a major cause of death of AML patients and results from immune evasion of AML blasts. Dysfunction of the p53 signaling pathway is frequent in AML and often caused by upregulation of the central p53 negative regulator Murine Double Minute 2 (MDM2). Besides its oncogenic effects p53 also regulates immune function and immune surveillance of solid cancer. We hypothesize that p53 also controls immune-related genes in AML cells and that p53 reactivation via MDM2-inhibition may enhance the immunogenicity of AML cells to allogeneic T cells.
 
Overall design In total 18 samples were analyzed, including 6 replicates from DMSO control, 6 replicates from MDM2 inhibitor RG7112 and 6 replictes from MDM2 inhibitor HDM201.
 
Contributor(s) Theresa L, Robert Z, Geoffroy A, Melanie B
Citation(s) 35853161
Submission date Sep 17, 2020
Last update date Sep 21, 2022
Contact name Geoffroy Andrieux
Organization name University clinics Freiburg
Street address Breisacherstr 153
City Freiburg
ZIP/Postal code 79110
Country Germany
 
Platforms (1)
GPL23159 [Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay)
Samples (18)
GSM4792226 DMSO_1
GSM4792227 DMSO_2
GSM4792228 DMSO_3
Relations
BioProject PRJNA664013

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE158103_RAW.tar 20.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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