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Series GSE158131 Query DataSets for GSE158131
Status Public on Sep 15, 2021
Title Gene expression in the hippocampal DG in WT and Cav3.1KO mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Low-threshold voltage gated T-type calcium channels are characterized by unique electrophysiological features with the fast inactivation and slow deactivation kinetics. Previous reports suggest that T-type calcium channels may be involved in the adult hippocampal neurogenesis, however, function of T-type calcium channels in newly generated cells is still uncertain. We demonstrated that Cav3.1 is predominantly localized in the NPCs in mouse SGZ, and that deletion of Cav3.1 attenuates proliferation and survival in 5-bromo-2'-deoxyuridine (BrdU)-labeled new born cells in the hippocampal DG. To reveal mechanism underlying impaired adult hippocampal neurogenesis in Cav3.1 KO mice, gene expression in the hippocampal DG is compared between WT and Cav3.1 KO mice. We here defined several altered genes related with cell apoptosis, proliferation and neuronal differentiation in Cav3.1 KO mice.
 
Overall design After decapitation of animals, brain tissue from hippocampal DG region was dissected and stored at −80 °C until assay. We assayed 4 brain slices of WT and Cav3.1 KO mice, respectively.
 
Contributor(s) Yabuki Y, Shioda N, Fukunaga K
Citation(s) 33393208
Submission date Sep 17, 2020
Last update date Jan 17, 2022
Contact name Satoshi Kondo
Organization name Toray Industries,Inc.
Street address 10-1 tebiro 6-chome
City Kamakura
State/province Kanagawa
ZIP/Postal code 248-8555
Country Japan
 
Platforms (1)
GPL22438 3D-Gene Mouse Oligo chip 24k V1.2.0
Samples (8)
GSM4792971 hippocampal DG WT1
GSM4792972 hippocampal DG WT2
GSM4792973 hippocampal DG WT3
Relations
BioProject PRJNA664099

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE158131_RAW.tar 3.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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