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| Status |
Public on Oct 06, 2021 |
| Title |
Transcriptomic profiling of guinea pigs with NASH and advanced fibrosis |
| Organism |
Cavia porcellus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Non-alcoholic steatohepatitis (NASH) is a serious health challenge affecting millions worldwide, and research advances are restricted by the limited availability of preclinical models recapitulating the complex disease etiology and hepatic histopathology. Uniquely, the diet induced guinea pig model develops NASH with fibrosis resembling human histopathology however, no data is available depicting the guinea pig NASH transcriptome. We provide the first high throughput sequencing results on guinea pig NASH with advanced fibrosis. Transcriptomic profiles in guinea pig NASH clearly separated from controls, and pathways involved in fibrosis, inflammation and lipid metabolism were all highly regulated.
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| Overall design |
Transcriptomic analysis was performed on 6 healthy and 6 guinea pigs with fibrotic NASH.
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| Contributor(s) |
Skat-Rørdam J, Højland-Ipsen D, Seeman S, Latta M, Lykkesfeldt J, Tveden-Nyborg P |
| Citation(s) |
34572384 |
| |
| Submission date |
Sep 17, 2020 |
| Last update date |
Oct 06, 2021 |
| Contact name |
Josephine Skat-Rørdam |
| E-mail(s) |
jsr@sund.ku.dk
|
| Organization name |
Københavns Universitet
|
| Department |
Department of Veterinary and Animal Sciences
|
| Street address |
Ridebanevej 9
|
| City |
Frederiksberg C. |
| ZIP/Postal code |
1870 |
| Country |
Denmark |
| |
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| Platforms (1) |
| GPL29163 |
Illumina NextSeq 500 (Cavia porcellus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA664197 |
| SRA |
SRP283117 |
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