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Status |
Public on Mar 01, 2022 |
Title |
Cmarr/miR-540-3p axis promotes cardiomyocyte maturation transition by orchestrating Dtna expression |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing
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Summary |
Here, our study showed that a heart-rich lncRNA, Cmarr, which is specifically upregulated during heart development, promoted the maturation transition of ESC-CMs. Cmarr interacted with miR-540-3p to increase the expression of Dtna (a key component of DGC), thus served as a new regulator of the DGC-YAP complex and cardiomyocyte maturation. Our study further identified that Cmarr could recover Dtna expression in the MI heart and attenuate the cardiac remodeling.
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Overall design |
RNA-seq and miRNA-seq of heart tissues
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Contributor(s) |
Wu Y, Guo X |
Citation(s) |
36035750 |
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Submission date |
Sep 18, 2020 |
Last update date |
Aug 31, 2022 |
Contact name |
Yukang Wu |
E-mail(s) |
yukang_wu@tongji.edu.cn
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Organization name |
tongji university
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Street address |
siping road 1239
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City |
shanghai |
ZIP/Postal code |
20092 |
Country |
China |
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Platforms (1) |
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Samples (10)
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Relations |
BioProject |
PRJNA664356 |
SRA |
SRP283452 |