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Series GSE158239 Query DataSets for GSE158239
Status Public on Jun 02, 2021
Title Functional characteriation of histone variant H2A.B in Hodgkin lymphoma
Organism Homo sapiens
Experiment type Other
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary The fact that the testis-specific H2A.B is ectopically expressed in Hodgkin lymphoma (HL) and its derived cell lines implicates H2A.B in having a role in oncogenesis (either as an oncogene or a tumour suppressor) similar to other epigenetic regulators of the testis. In order to understand the mechanism of H2A.B-mediated epigenetic regulation in Hodgkin lymphoa, the epigenomic profiles of pan-H2A.B and major H2A.B post-translational modificaitons were investigated using the CUT&RUN method.
 
Overall design Epigenomic profiling of pan- and post-translationally modified H2A.B in L1236 and L428 cell lines.
 
Contributor(s) Jiang X, Wen J, Soboleva T, Tremethick D
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Sep 18, 2020
Last update date Jun 03, 2021
Contact name Jiayu Wen
Organization name John Curtin School of Medical Research, The Australian National University
Department Department of Genome Science
Lab The Wen Lab
Street address 133 Garran Rd
City CANBERRA
State/province ACT
ZIP/Postal code 2601
Country Australia
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (28)
GSM4795744 L428_H2A.B_rep1 (CUT&RUN)
GSM4795745 L428_IgG_rep1 (CUT&RUN)
GSM4795746 L1236_H2A.B_rep1 (CUT&RUN)
Relations
BioProject PRJNA664403
SRA SRP283897

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE158239_L1236_H2AB_RNAseq_counts.xlsx 1.5 Mb (ftp)(http) XLSX
GSE158239_L1236_H2AB_q20_nodup_spikeins_norm.bw 1.3 Gb (ftp)(http) BW
GSE158239_L1236_IgG_q20_nodup_spikeins_norm.bw 515.6 Mb (ftp)(http) BW
GSE158239_L1236_KD_q20_nodup_norm.bw 1.3 Gb (ftp)(http) BW
GSE158239_L1236_NTC_q20_nodup_norm.bw 1.4 Gb (ftp)(http) BW
GSE158239_L428_H2AB_RNAseq_counts.xlsx 1.5 Mb (ftp)(http) XLSX
GSE158239_L428_H2AB_q20_nodup_spikeins_norm.bw 2.3 Gb (ftp)(http) BW
GSE158239_L428_IgG_q20_nodup_spikeins_norm.bw 817.4 Mb (ftp)(http) BW
GSE158239_L428_KD_q20_nodup_norm.bw 1.6 Gb (ftp)(http) BW
GSE158239_L428_NTC_q20_nodup_norm.bw 1.8 Gb (ftp)(http) BW
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