|
| Status |
Public on Jan 31, 2021 |
| Title |
Copper Availability Influences the Transcriptomic Response of C. albicans to Fluconazole Stress |
| Organism |
Candida albicans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We used whole transcriptome profiling (RNA-seq) to analyze the effects of Cu availability on the transcriptomic response of Candida albicans to the azole antifungal drug fluconazole. This study provides a framework for understanding how two treatments work in concert to generate unique impacts on stress response mechanisms of pathogenic fungi.
|
| |
|
| Overall design |
Examination of Candida albicans cells treated with fluconazole under basal and elevated (10 µM) Cu conditions.
|
| |
|
| Contributor(s) |
Hunsaker EW, Yu C, Franz KJ |
| Citation(s) |
33693623 |
| |
| Submission date |
Oct 19, 2020 |
| Last update date |
Apr 28, 2021 |
| Contact name |
Katherine J. Franz |
| E-mail(s) |
katherine.franz@duke.edu
|
| Phone |
9196601541
|
| Organization name |
Duke University
|
| Department |
Chemistry
|
| Street address |
2103 French Science Center, 124 Science Dr., Box 90346
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27708-0346 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL28323 |
Illumina NovaSeq 6000 (Candida albicans) |
|
| Samples (75)
|
|
| Relations |
| BioProject |
PRJNA669679 |
| SRA |
SRP287539 |
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