GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE159881 Query DataSets for GSE159881
Status Public on Oct 01, 2023
Title Identification of translational microRNA biomarker candidates for nano-polystyrene induced brain injury using next-generation sequencing
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The exposure to nano-plastics affects mammalian neurotoxic hazard characterization remains to be determined. Our aim was to investigate the neurotoxicity of nano-plastics in rodents. Animals were randomly divided into two groups: a control group and 50 mg/kg body weight PS NPs treatment groups. Before treatment, animals were fasted overnight. PS NPs were suspended into waters, vigorously stirred. The PS NPs via oral gavage once per day and for 6 months. The mice were treated with water in control group. We found that exposure to PS NPs caused cognitive decline. PS NPs exposure influenced the prefrontal cortex cells with more pathological alteration with increasing dosage. High-throughput RNA sequencing was conducted to explore miRNA expression in prefrontal cortex. Twenty-nine differentially expressed miRNAs were detected, including 12 upregulated and 17 downregulated miRNAs. This finding provided a reference for further studies on the development mechanisms of ncRNA during cognitive dysfunction.
Overall design Mice exposure PS NPs for half year and identified of translational microRNA
Contributor(s) Chen C, Rong Z
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Oct 22, 2020
Last update date Oct 01, 2023
Contact name chu chen
Organization name Hebei medical university
Department Department of Toxicology
Street address 361 Zhongshan East Road
City Shijiazhuang
State/province Hebei
ZIP/Postal code 050017
Country China
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM4849244 CON_1
GSM4849245 CON_2
GSM4849246 CON_3
BioProject PRJNA670714
SRA SRP288183

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE159881_Processed_data-cc.xlsx 149.4 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap