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| Status |
Public on Jan 01, 2010 |
| Title |
Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C |
| Organism |
Xenopus laevis |
| Experiment type |
Expression profiling by array
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| Summary |
Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles.
Keywords: co-expression design,development or differentiation design,reference design,time series design
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| Overall design |
Overall design: Thyroid hormone (TH) controls remodeling of the pancreas. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis.. This is part 3, done on the 22K Xenopus platform version 2. This dataset was from pancreas of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate.
Samples in all 3 parts of the study received the same thyroid hormone levels.
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| Citation(s) |
19896938 |
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| Submission date |
May 07, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Donald Brown |
| E-mail(s) |
brown@ciwemb.edu
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| Organization name |
Carnegie Institution
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| Department |
Department of Embryology
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| Street address |
3520 San Martin Dr
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21218 |
| Country |
USA |
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| Platforms (1) |
| GPL3936 |
Carnegie Xenopus laevis 22k Micorarray v2 |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE16075 |
Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver |
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| Relations |
| BioProject |
PRJNA123085 |
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