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| Status |
Public on Dec 31, 2021 |
| Title |
IL-36 and IL-17A Cooperatively Induce a Psoriasis-like Gene Expression Response in Human Keratinocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study we tested interactions between IL-36 and IL-17A in human keratinocytes. 24 hours of IL-36 stimulation in keratinocytes promoted IL-36, IL-17C, and characteristic psoriasis-related molecule expressions in normal human epidermal keratinocytes in dose-dependent manners as measured by mRNA and protein quantification.
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| Overall design |
12 cultured samples of human keratinocytes stimulated with IL-36 and IL-17 family cytokines, as single cytokines and also as a combination were evaluated by gene expression profiling with Affymetrix U133 2.0Plus arrays
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| Contributor(s) |
Krueger JG, Miura S, Garcet S |
| Citation(s) |
33675789 |
| |
| Submission date |
Nov 05, 2020 |
| Last update date |
Jul 01, 2022 |
| Contact name |
James Krueger |
| E-mail(s) |
kruegej@rockefeller.edu
|
| Phone |
212-327-7730
|
| Organization name |
The Rockefeller University
|
| Department |
Center for Clinical and Translational Science
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| Lab |
Laboratory of Investigative Dermatology
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| Street address |
1230 York Avenue
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA674819 |
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