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| Status |
Public on Dec 03, 2020 |
| Title |
In vitro antifungal activity of myriocin against drug-resistant Candida auris strains |
| Organism |
Candidozyma auris |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Myriocin exhibited very low MIC values (0.016 to 0.4 mg/L) to all C. auris isolates including several multidrug-resistant strains. The yeast-form, filamentous, or aggregating-form cells were all susceptible to the chemical. The antifungal effect was majorly due to the fungistatic activity, although an extended treatment could lead to the fungicidal activity to C. auris cells. Transcriptomic analysis demonstrates that myriocin suppresses the cellular metabolic activity and induces the expression of stress or antifungal response genes.
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| |
|
| Overall design |
total RNA profiles of Candida auris cells treated with Myriocin and DMSO
|
| |
|
| Contributor(s) |
Huang G, Bing J, Guan Z |
| Citation missing |
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| |
| Submission date |
Nov 17, 2020 |
| Last update date |
Dec 03, 2020 |
| Contact name |
Jian Bing |
| E-mail(s) |
bingj@fudan.edu.cn
|
| Organization name |
Fudan University
|
| Department |
School of Life Sciences
|
| Street address |
Songhu Road, Yangpu District
|
| City |
Shanghai |
| ZIP/Postal code |
200438 |
| Country |
China |
| |
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| Platforms (1) |
| GPL28368 |
Illumina NovaSeq 6000 ([Candida] auris) |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA678875 |
| SRA |
SRP292870 |
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