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Series GSE161653 Query DataSets for GSE161653
Status Public on Nov 01, 2022
Title Gene expression in activated WT or PDK4 -/- CD4+ T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Activation of CD4+ T cells requires metabolic reprograming to sustain demands of cellular building blocks and ATP. Pyruvate dehydrogenase kinase (PDK) is an enzyme regulating pyruvate dehydrogenase complex subunit alpha 1 (PDHE1-alpha), which converts pyruvate to acetyl-CoA. Gene expression analysis of TCR-stimulated CD4+ T cells with PDK4 deletion exhibited the reduced calcium signaling and aerobic glycolysis pathway.
Overall design Comparing gene expression of WT and PDK4 deficient CD4+ T cells
Contributor(s) Lee H, Kim ES, Lee I
Citation(s) 36229019
Submission date Nov 17, 2020
Last update date Nov 02, 2022
Contact name Hoyul Lee
Organization name Kyungpook Nationatl University Hospital
Department Bio-medical Research Institute
Street address 807, Hoguk-ro, Buk-gu
City Daegu
ZIP/Postal code 41404
Country South Korea
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (4)
GSM4912030 WT 1
GSM4912031 WT 2
GSM4912032 KO 1
BioProject PRJNA679025
SRA SRP292939

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE161653_RAW.tar 470.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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