|
| Status |
Public on May 21, 2009 |
| Title |
Expression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of differentially expressed genes on chromosome 21 using Gene Set Enrichment Analysis. Functional pathway analysis of the resulting genes highlighted the importance of oxidative stress, ion transport, and G-protein signaling in the DS fetuses.
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| |
|
| Overall design |
We profiled seven DS expression samples and seven controls matched for gender and approximate gestational age..
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| |
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| Contributor(s) |
Slonim DK, Koide K, Johnson KL, Tantravahi U, Cowan JM, Jarrah Z, Bianchi DW |
| Citation(s) |
19474297 |
| Submission date |
May 20, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Donna K Slonim |
| E-mail(s) |
Donna.Slonim@tufts.edu
|
| Organization name |
Tufts University
|
| Department |
Computer Science
|
| Street address |
161 College Ave.
|
| City |
Medford |
| State/province |
MA |
| ZIP/Postal code |
01845 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (14)
|
| GSM406286 |
second_trimester_amniotic_fluid_euploid_female1 |
| GSM406287 |
second_trimester_amniotic_fluid_Down_syndrome_female_1 |
| GSM406288 |
second_trimester_amniotic_fluid_euploid_female2 |
| GSM406289 |
second_trimester_amniotic_fluid_Down_syndrome_female_2 |
| GSM406290 |
second_trimester_amniotic_fluid_euploid_male_1 |
| GSM406291 |
second_trimester_amniotic_fluid_Down_syndrome_male_1 |
| GSM406292 |
second_trimester_amniotic_fluid_euploid_male_2 |
| GSM406293 |
second_trimester_amniotic_fluid_Down_syndrome_male_2 |
| GSM406294 |
second_trimester_amniotic_fluid_euploid_male_3 |
| GSM406295 |
second_trimester_amniotic_fluid_Down_syndrome_male_3 |
| GSM406296 |
second_trimester_amniotic_fluid_euploid_male_4 |
| GSM406297 |
second_trimester_amniotic_fluid_Down_syndrome_male_4 |
| GSM406298 |
second_trimester_amniotic_fluid_euploid_male_5 |
| GSM406299 |
second_trimester_amniotic_fluid_Down_syndrome_male_5 |
|
| Relations |
| BioProject |
PRJNA115063 |
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