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Series GSE162844 Query DataSets for GSE162844
Status Public on Nov 22, 2021
Title 16S V3-V4 -based microbial profiling of matched healthy and inflamed ileal mucosa from patients affected by Crohn’s disease
Organism human gut metagenome
Experiment type Other
Summary Crohn’s Disease (CD) pathogenesis is still unclear. Disorders in the mucosal immunoregulation and its crosstalk with the microbiota may represent an important component in tissue injury. We aimed to characterize the molecular immune response distribution within the ileal layers ( mucosa, submucosa and serosa) and to evaluate the correlated microbiota in pathological/healthy settings comparing first surgery/relapse clinical conditions.
Overall design 10 matched pairs of paraffin-embedded ileal tissue specimens was extracted and 16S rDNA amplicons (V3-V4 region)
Contributor(s) Ramazzotti M, Amedei A
Citation(s) 33611347, 35967326
Submission date Dec 08, 2020
Last update date Aug 24, 2022
Contact name Matteo Ramazzotti
Organization name University of Florence
Department Experimental and Clinical Biomedical Sciences
Street address viale Morgagni 50
City Firenze
ZIP/Postal code 50134
Country Italy
Platforms (1)
GPL29483 Illumina MiSeq (human gut metagenome)
Samples (20)
GSM4962775 non inflamed sample S05 from patient M
GSM4962776 non inflamed sample S07 from patient M
GSM4962777 non inflamed sample S10 from patient F
BioProject PRJNA683584
SRA SRP297049

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE162844_otu_tax.txt.gz 12.0 Kb (ftp)(http) TXT
GSE162844_otus.fasta.gz 132.8 Kb (ftp)(http) FASTA
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Raw data are available in SRA
Processed data are available on Series record

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