|
| Status |
Public on Jul 13, 2021 |
| Title |
The p53 transcriptional response across tumor types reveals core and outcome-specific signatures modulated by cis-regulatory lncRNAs [ChIP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The p53 pathway is a universal tumor suppressor mechanism but the differences of the p53 transcriptional response to oncogenic stress across different tumor types are poorly understood. Using a panel of murine cancer cell lines, we observed that the majority of p53-bound sites were tumor type-specific. Analysis of common p53 targets defined a small but robust core signature and revealed a senescence-specific repression geneset. Characterization of novel transcripts identified p53-induced lncRNAs, which frequently associated with chromatin and regulated their neighboring mRNAs. These findings shed light on the unique and shared p53 transcriptional signatures across different contexts and clarify the contributions of lncRNAs to the p53 transcriptome.
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| |
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| Overall design |
p53 ChIPseq of K-rasG12D; p53LSL/LSL; Rosa26-CreERT2 (KPR) cell lines isolated from murine lung adenocarcinomas (LA), sarcomas (SA), and lymphomas (LY)
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| |
|
| Contributor(s) |
Zamudio JR |
| Citation(s) |
34326251 |
| |
| Submission date |
Dec 17, 2020 |
| Last update date |
Aug 31, 2021 |
| Contact name |
Jesse R Zamudio |
| E-mail(s) |
jesse.zamudio@ucla.edu
|
| Organization name |
University of California, Los Angeles
|
| Department |
MCDB
|
| Lab |
Zamudio
|
| Street address |
610 CHARLES E. YOUNG DRIVE EAST BOX 957239
|
| City |
LOS ANGELES |
| State/province |
CA |
| ZIP/Postal code |
90095-7239 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (24)
|
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| This SubSeries is part of SuperSeries: |
| GSE163404 |
The p53 transcriptional response across tumor types reveals core and outcome-specific signatures modulated by cis-regulatory lncRNAs |
|
| Relations |
| BioProject |
PRJNA686001 |
| SRA |
SRP298307 |
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