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| Status |
Public on Dec 18, 2020 |
| Title |
DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life |
| Organism |
Cavia porcellus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
We examined the hypothesis that prenatal synthetic glucocorticoids (sGC) administration alters DNA methylation signatures in Guinea pig offspring hippocampus and whole blood. Guinea pigs were treated with sGC or saline in late gestation. Genome-wide modifications of DNA methylation were analyzed using reduced representation bisulfite sequencing in juvenile female offspring.
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| |
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| Overall design |
sGC to saline control comparisons for the hippocampus (HPC: n=6/condition, total of 12) and for whole blood (BL: n=6/condition, total of 12) within the same female offspring
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| |
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| Contributor(s) |
Sasaki A, Matthews SG |
| Citation(s) |
33462183 |
| |
| Submission date |
Dec 17, 2020 |
| Last update date |
Feb 01, 2021 |
| Contact name |
Stephen Matthews |
| Organization name |
University of Toronto
|
| Street address |
1 King's College Circle
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5S1A8 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL29163 |
Illumina NextSeq 500 (Cavia porcellus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA686115 |
| SRA |
SRP298359 |
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