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| Status |
Public on Dec 29, 2020 |
| Title |
Differential expression profiles of plasma tsRNAs in children with fulminant myocarditis |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
We report the application of high-throughput RNA sequencing technology to examine expression profiling of plasma transfer RNA (tRNA)-derived small RNAs (tsRNAs) in children with fulminant myocarditis during acute phase (FM-A group), children with fulminant myocarditis during convalescent phase (FM-C group), and healthy volunteers (Con group). A total of 750 precisely matched tsRNAs were identified in the plasma from the three groups. We find that a total of 13 tsRNAs were differentially expressed in FM-A and CON samples, of which 11 tsRNAs were upregulated and 2 were downregulated, and 694 tsRNAs were excluded ; a total of 8 tsRNAs were differentially expressed in paired FM-C and CON samples, of which 2 tsRNAs were upregulated and 6 were downregulated and 703 tsRNAs were excluded . This study provides new ideas for future research on elucidating the mechanisms of myocarditis through regulating tsRNAs levels.
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| Overall design |
Examination of different expression profiling of tsRNAs in children with fulminant myocarditis.
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| Contributor(s) |
Wang J, Han B, Zhang L, Lv J, Wang Y, Yang X, Jiang D, Yi Y, Zhang J |
| Citation(s) |
34114472 |
| |
| Submission date |
Dec 28, 2020 |
| Last update date |
Jun 12, 2021 |
| Contact name |
Jing Wang |
| E-mail(s) |
legend@fudan.edu.cn
|
| Phone |
+86 15168863836
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| Organization name |
Shandong Provincial Hospital
|
| Street address |
No. 324, jingwuweiqi road, huaiyin district
|
| City |
Jinan |
| ZIP/Postal code |
250021 |
| Country |
China |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA688297 |
| SRA |
SRP299510 |
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