|
| Status |
Public on Jan 16, 2021 |
| Title |
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal true BMI loci [hMSC_adipocytes_atacseq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We investigated whether intersecting functional genomic data (ATAC-seq + promoter focused Capture C) with increasingly powered publically available GWAS for Body Mass Index and Waist to Hip Ratio could identify additional true postiive subsignficant signals (5x10-8< P value < 5x10-4) without increasing the GWAS sample size
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| Overall design |
We performed ATAC-seq and Promoter Focused Capture C on MSC dervived adipocytes from healthy donors
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| Contributor(s) |
Hammond R, Pahl MC, Su C, Pippin JA, Wagley Y, Chesi A, Hankenson KD, Grant SF |
| Citation(s) |
33459256 |
| |
| Submission date |
Jan 13, 2021 |
| Last update date |
Apr 17, 2021 |
| Contact name |
Matthew C Pahl |
| E-mail(s) |
pahlm@email.chop.edu
|
| Phone |
5704282303
|
| Organization name |
Children's Hospital of Philadelphia
|
| Department |
Center for Spatial and Functional Genomics
|
| Lab |
Struan Grant and Andrew Wells
|
| Street address |
3615 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE164912 |
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal true BMI loci. |
|
| Relations |
| BioProject |
PRJNA691887 |
| SRA |
SRP301594 |
