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Status |
Public on Jan 21, 2021 |
Title |
RNA seq of sorted T cell subsets from PBMCs and rectal biopsies from humans and rhesus macaques |
Organisms |
Macaca mulatta; Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Memory CD4 T cells facilitate HIV establishment following transmission and contribute to HIV persistence during suppressive antiretroviral therapy (ART). Numerous studies have highlighted the importance of memory CD4 T cells expressing the surface integrin heterodimer, α4β7 in HIV infection. Here, we focused on delineating the molecular characteristics of α4β7+ CD4 T cells and determining how transcriptional profiles of circulating α4β7hi CD4 T cells corresponded to that within the lower GI tract.
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Overall design |
Comparision of transciptome profiles across blood and gut compartment
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Contributor(s) |
Iyer SS |
Citation missing |
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Submission date |
Jan 20, 2021 |
Last update date |
Jan 24, 2021 |
Contact name |
Smita Iyer |
E-mail(s) |
smiyer@ucdavis.edu
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Organization name |
University of California-Davis
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Department |
Center for Immunology and Infectious Disease
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Street address |
county rd 98 & hutchison, ccm room 2075
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City |
Davis |
State/province |
CA |
ZIP/Postal code |
95616 |
Country |
USA |
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Platforms (2) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
GPL23949 |
Illumina HiSeq 4000 (Macaca mulatta) |
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Samples (70)
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Relations |
BioProject |
PRJNA693560 |
SRA |
SRP302591 |