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| Status |
Public on Jan 23, 2021 |
| Title |
Transcriptomic response of Cryptococcus neoformans to ecologically relevant nitrogen concentrations |
| Organism |
Cryptococcus neoformans |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We examine the transcriptomic response of Cryptococcus neoformans to two different ecologically relevant nitrogen concentrations. Our data revealed that low nitrogen conditions modulate the expression of numerous virulence genes in C. neoformans. Among these were, CTR4 and CGP1, which showed highly significant modulation under low nitrogen conditions. Furthermore, data analysis revealed the upregulation of antifungal tolerance-related genes in low nitrogen conditions, including genes involved in ergosterol biosynthetic processes and cell wall integrity. Overall, our findings provide insight into the survival of C. neoformans in nitrogen-poor ecological niches and suggest that pre-adaptation to these conditions may influence the pathobiology of this yeast.
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| |
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| Overall design |
Examination of the C. neoformans transcriptome during growth in high and low nitrogen conditions
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| |
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| Contributor(s) |
Bosch C, Bhana Z, Toplis B, Volschenk H, Botha A |
| Citation missing |
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| |
| Submission date |
Jan 22, 2021 |
| Last update date |
Jan 23, 2021 |
| Contact name |
Caylin Bosch |
| E-mail(s) |
18344666@sun.ac.za
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| Organization name |
Stellenbosch University
|
| Department |
Microbiology
|
| Street address |
JC Smuts Building, Van der Byl road
|
| City |
Stellenbosch |
| State/province |
Western Cape |
| ZIP/Postal code |
7600 |
| Country |
South Africa |
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| Platforms (1) |
| GPL29638 |
Ion Torrent S5 (Cryptococcus neoformans) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA694029 |
| SRA |
SRP302835 |
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