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| Status |
Public on Mar 08, 2021 |
| Title |
Characterizing senescent lung epithelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We characterized senescent alveolar epithelial cells in an effort to better understand how these cells contribute to lung remodeling and fibrosis. The transcriptional profiles of several different types of senescent lung epithelial cells was evaluated using various induction methods in order to better understand core characteristics associated with the senescent program in epithelial cells of the lung.
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| Overall design |
Three separate cell types have been subjected to hydrogen peroxide or doxorubicin treatment in order to induce senescence, as evidenced by positive staining for senescent-associated beta-galactosidase activity. This gave us the opportunity to look at senescence in different cell types and with differing methods of induction.
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| |
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| Contributor(s) |
DePianto DJ, Morshead KB, Vander Heiden JA, Arron JR |
| Citation(s) |
33705361 |
| |
| Submission date |
Feb 02, 2021 |
| Last update date |
May 25, 2021 |
| Contact name |
Jason Anthony Vander Heiden |
| E-mail(s) |
vandej27@gene.com
|
| Organization name |
Genentech
|
| Department |
Biological Research AI Development
|
| Street address |
1 DNA Way
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE166059 |
Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population |
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| Relations |
| BioProject |
PRJNA699009 |
| SRA |
SRP304378 |
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