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| Status |
Public on Jul 01, 2021 |
| Title |
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our results demonstated that OICR-9429 a inhibitor of WDR5, could supress the proliferation and chemo-resistance of prostate cancer cells. To explore the molecular mechanism underlying OICR-9429-induced WDR5 inhibition in Prostate cancer cells, we conducted a genome-wide RNA-sequencing to compare gene expression profiles between OICR-9429 treated DU145, PC3-3 cells and their control cells
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| Overall design |
After treated with OICR-9429 or DMSO for 48h, respectively. The RNA of the corresponding treated cells (including DU145 and PC-3) was extracted and sequenced on Illumina HiSeq 2500 platform and 100-bp paired-end reads were generated.
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| Contributor(s) |
Zhou Q, Lin T, Huang J |
| Citation missing |
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| |
| Submission date |
Feb 04, 2021 |
| Last update date |
Jul 02, 2021 |
| Contact name |
Qianghua Zhou |
| E-mail(s) |
zhouqh6@mail2.sysu.edu.cn
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| Organization name |
sun yat-sen university
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| Street address |
107th Yanjiangxi Road, Guangzhou
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| City |
Guangzhou |
| ZIP/Postal code |
510020 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA699435 |
| SRA |
SRP304676 |
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