|
| Status |
Public on Aug 15, 2009 |
| Title |
ChIP-on-chip from acute myeloid leukemia cell lines and clinical samples for H3K4me3, H3K27me3, and EZH2 |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
|
| Summary |
Histone modifcations at the p15INK4b gene were compared in sample with p15INK4b DNA methylation vs. samples with no DNA methylation
AML clinical samples without DNA methylation exhibit bivalent histone modifications at p15INK4b, while clinical samples with DNA methylation display lower H3K4me3 and retain H3K27me3
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| |
|
| Overall design |
Comparison of AML cell lines and clinical samples with p15INK4b DNA methylation to those free of DNA methylation. AML cell lines KG-1, KG-1a Kasumi-1, AML-193 have p15INK4b DNA methylation. AML patient samples AML6, AML7, AML8 have p15INK4b DNA methylation.
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| |
|
| Contributor(s) |
Paul TA, Wolff L |
| Citation(s) |
20190193 |
| |
| Submission date |
Jun 19, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Thomas A Paul |
| E-mail(s) |
paulth@mail.nih.gov
|
| Phone |
301-435-5571
|
| Fax |
301-594-3996
|
| Organization name |
NCI-CCR
|
| Department |
Laboratory of Cellular Oncology
|
| Street address |
37 Convent Dr.
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL8754 |
chromosome 9 INK locus tiling array |
|
| Samples (40)
|
|
| Relations |
| BioProject |
PRJNA117419 |
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