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Status |
Public on Feb 24, 2021 |
Title |
lncRNA profiles enable prognosis prediction and subtyping for esophageal squamous cell carcinoma |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
AC007128.1, a long non-coding RNA, was upregulated in both ESCC tissues and cells, and associated with poor prognosis in ESCC. AC007128.1 can promote migration and invasion in ESCC cell lines. By RNA-sequencing analysis, we observed the significant changes of genes important in AC007128.1-depleted cells. We generated two KYSE150 cell lines stably transduced with either a sh-NC lentiviral construct or a shRNA lentiviral construct designed to target AC007128.1 RNA to investigate the consequences on the gene expression profile of AC007128.1 knockdown in KYSE150 cells.
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Overall design |
The gene expression of 3 samples from shAC007128.1 KYSE150 cell line was compared to 3 samples from shCtrl by RNA sequencing.
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Contributor(s) |
Zhang S |
Citation(s) |
34127945 |
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Submission date |
Feb 23, 2021 |
Last update date |
Jun 30, 2021 |
Contact name |
chuanxin wang |
E-mail(s) |
cxwang@sdu.edu.cn
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Organization name |
The Second Hospital of Shandong University
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Street address |
247 Beiyuan Street, Jinan 250033, Shandong, China,
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City |
Jinan |
ZIP/Postal code |
250033 |
Country |
China |
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Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (6)
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Relations |
BioProject |
PRJNA704364 |
SRA |
SRP307746 |