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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 28, 2022 |
| Title |
Telocytes regulate tissue resident macrophages in periodontal disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
A small population of telocytes (TC) have been identified in periodontium. They are quiescent in homeostasis, however, in periodontitis, they are activated by LPS via the receptor Lbp, which causes TCs to send HGF signals to the LPS activated iNOS+ (M1) macrophages. Macrophages receive the HGF signals via c-Met, which further causes the expression of M2 marker Arg1, representing in an increase of M2 macrophages. The expression of Arg1 can be inhibited by a HGF/c-Met selective inhibitor Tivantinib.
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| Overall design |
Mouse PDL mRNA profiles during periodontitis.
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| Contributor(s) |
Zhao J, Sharpe P |
| Citation(s) |
36193890 |
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| Submission date |
Feb 28, 2021 |
| Last update date |
Oct 28, 2022 |
| Contact name |
Paul Sharpe |
| Organization name |
King's college London
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| Street address |
Craniofacial Development & Stem cell bio, Guy's Tower Floor 27
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| City |
london |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (1) |
| GSM5115470 |
Periodontal ligament tissue periodontitis |
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| Relations |
| BioProject |
PRJNA705494 |
| SRA |
SRP308587 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE167917_RAW.tar |
1.2 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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