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| Status |
Public on Nov 18, 2004 |
| Title |
Effect of CCL3 on target ablation-induced macrophage recruitment into the olfactory epithelium |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The aim was to determine the identity of genes regulated at 3 d post-olfactory bulbectomy in the olfactory mucosa of carrier-injected Ccl3-/- mice compared with carrier-injected C57BL/6 mice. Total RNA from the OE was hybridized to Affymetrix microarrays. A number of chemokine-, cytokine-, and growth factor-related genes were significantly regulated in the Ccl3-/- mice, and were restored in CCL3 protein-injected Ccl3-/- mice. The results illustrated that CCL3 played a key role in recruitment of macrophages to the OE and provided insight into the genomic regulation involved in OE remodeling.
Keywords: other
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| Contributor(s) |
Kwong K, Vaishnav RA, Liu Y, Subhedar N, Stromberg AJ, Getchell ML, Getchell TV |
| Citation(s) |
15467013 |
| |
| Submission date |
Aug 12, 2004 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Kevin Kwong |
| E-mail(s) |
kevin.kwong@uky.edu
|
| Phone |
(859) 257-1412 x319
|
| Organization name |
University of Kentucky
|
| Department |
Physiology
|
| Lab |
Getchell Lab
|
| Street address |
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| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40536 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA90665 |
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