Transcriptomic evaluation of age-associated CNS-resident CD8 memory T cells identifies CD200R1 as an important regulator of T cell entry and activation
Expression profiling by high throughput sequencing
Summary
We report a novel role for the CD200-CD200R1 pathway in regulating the basal entry and activation of resident memory phenotype CD8 T cells in the brain and other non-lymphoid tissues.
Overall design
Brain and spleen CD8 T cells (CD44HiCD62LLo) were isolated by FACS, Cells were stimulated with or without PMA/ionomycin for 2 hours to were subjected to RNA-sequecing
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