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Series GSE169252 Query DataSets for GSE169252
Status Public on Mar 30, 2021
Title CD22 blockage restores age-related impairments of microglia surveillance capacity
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We report that antibody-mediated CD22 blockage leads to an altered transcriptomic signature profile which, by further evaluating the affected genes, resembles a homeostatic phenotype.
Overall design Assessment of RNA expression levels following antibody-mediated blockage of CD22 in human iPSC-derived macrophages.
Contributor(s) Schmucki R, Kueng E, Ebeling M, Gutbier S, Harde E
Citation(s) 33613545, 34140954
Submission date Mar 19, 2021
Last update date Jul 01, 2021
Contact name Roland Schmucki
Organization name F. Hoffmann - La Roche AG
Street address Grenzacherstrase
City Basel
ZIP/Postal code 4058
Country Switzerland
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (16)
GSM5191564 untreated replicate 0
GSM5191565 anti-CD22 antibody replicate 0
GSM5191566 untreated replicate 1
BioProject PRJNA715777
SRA SRP311390

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE169252_CD22_counts.gct.gz 39.2 Kb (ftp)(http) GCT
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Raw data are available in SRA
Processed data are available on Series record

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