|
| Status |
Public on Dec 01, 2021 |
| Title |
Torque Teno Mini Virus as a cause of childhood acute promyelocytic leukemia lacking PML/RARA fusion |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We describe a case of a child affected by a relapsed PML/RARA-negative acute promyelocytic leukemia (APL) rescued by a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) and subsequent HSCT. We provide evidence of the presence of a chimeric viral transcript generated through genomic integration of a Torque Teno Mini Virus sequence into RARA intron 2, the recurrent breakpoint of all chimeric RARA fusions found in APL. This generates an in-frame TTMV/RARA chimeric fusion that is highly expressed at disease diagnosis and relapse and fully cleared at remission achievement.
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| |
|
| Overall design |
Whole transcriptome sequencing of acute promyelocytic leukemia lacking PML/RARA fusion
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| |
|
| Contributor(s) |
Indio V, Astolfi A |
| Citation(s) |
34432867 |
| |
| Submission date |
Mar 24, 2021 |
| Last update date |
Dec 03, 2021 |
| Contact name |
Valentina Indio |
| Organization name |
University of Bologna
|
| Street address |
via Giuseppe Massarenti,11
|
| City |
Bologna |
| State/province |
Bologna |
| ZIP/Postal code |
40127 |
| Country |
Italy |
| |
|
| Platforms (2) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA716977 |
| SRA |
SRP311958 |
