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| Status |
Public on Feb 02, 2010 |
| Title |
Gene expression analysis of TSC-tubers reveals increased expression of adhesion and inflammatory factors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cortical tubers in patients with tuberous sclerosis complex (TSC) are associated with cognitive disability and intractable epilepsy. While these developmental malformations are believed to result from the effects of TSC1 or TSC2 Gene mutations, the molecular mechanisms leading to tuber formation during brain development as well as the onset of seizures remain largely unknown. We used the Affymetrix Gene Chip platform as a genome-wide strategy to define the Gene expression profile of cortical tubers resected during epilepsy surgery compared to histologically normal perituberal tissue (adjacent to the cortical tuber) from the same patients or autopsy control tissue.
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| Overall design |
Gene expression profiles of cortical tubers were compared with autopsy control specimens and perituberal tissue from the same patients.
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| Contributor(s) |
Boer K, Gorter JA, Crino PB, Nellist M, Jansen FE, Spliet WG, van Rijen PC, Wittink FR, Breit TM, Troost D, Wadman WJ, Aronica E |
| Citation(s) |
19912235 |
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| Submission date |
Jul 06, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Floyd Wittink |
| E-mail(s) |
wittink@science.uva.nl
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| Phone |
+31205257937
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| Fax |
-
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| URL |
http://www.micro-array.nl
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| Organization name |
Universiteit van Amsterdam
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| Department |
MAD
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| Lab |
MAD
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| Street address |
Kruislaan 318
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| City |
Amsterdam |
| State/province |
- |
| ZIP/Postal code |
1098 SM |
| Country |
Netherlands |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA117259 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16969_RAW.tar |
50.5 Mb |
(http)(custom) |
TAR (of CEL, CHP, EXP, JPG) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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