|
| Status |
Public on Apr 20, 2022 |
| Title |
Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A I |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The purpose of this study was to decipher the molecular network underlying the synergy between the GATA1s mutation and loss of Arid3a. We used gene expression profiling (RNA-Seq) to evaluate gene expression changes upon gain and loss of Arid3a in the context of the Gata1s mutation
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| |
|
| Overall design |
We modulated levels of Arid3a in Gata1s-fetal liver cells
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| |
|
| Contributor(s) |
Alejo-Valle O, Klusmann J |
| Citation(s) |
34570885 |
| |
| Submission date |
Mar 26, 2021 |
| Last update date |
Apr 22, 2022 |
| Contact name |
Jan-Henning Klusmann |
| E-mail(s) |
jan-henning.klusmann@kgu.de
|
| Organization name |
Goehte University Frankfurt
|
| Department |
Pediatric Hematology and Oncology
|
| Street address |
Theodor-Stern-Kai 7
|
| City |
Frankfurt |
| ZIP/Postal code |
60590 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (17)
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| Relations |
| BioProject |
PRJNA717774 |
| SRA |
SRP312351 |
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