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| Status |
Public on Jul 15, 2009 |
| Title |
Cell Adhesion Molecule 1 (CADM1): A Novel Risk Factor for Venous Thrombosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Protein C (PC) deficiency increases the risk of venous thrombosis (VT) among members of Kindred Vermont II, but fails to fully account for the inheritance pattern. A genome scan of the pedigree supported the presence of a prothrombotic gene on chromosome 11q23 with weaker support on chromosomes 10p12 and 18p11.2-q11.
Preliminary data from Affimetrix microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT.
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| Overall design |
We obtained BOEC (blood outgrowth endothelial cells) from 3 female kindred subjects (ages 56, 61, and 74) with Protein C Deficiency. We also performed microarray analysis on BOEC from 27 normal subjects of diverse ages.
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| Contributor(s) |
Milbauer LC, Wei P, Enenstein J, Hebbel RP, Bovill EG |
| Citation(s) |
19643986 |
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| Submission date |
Jul 14, 2009 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Robert P. Hebbel |
| E-mail(s) |
enens001@umn.edu
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| Phone |
612-6244620
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| Fax |
612-625-8105
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| Organization name |
University of Minnesota
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| Department |
Medicine
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| Lab |
Vascular Biology Center
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| Street address |
MMC 480, 420 Delaware St. SE
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| City |
Minneapolis |
| State/province |
MN |
| ZIP/Postal code |
55455 |
| Country |
USA |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (30)
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| GSM249428 |
BOEC, normal 4 |
| GSM249429 |
BOEC, normal 5 |
| GSM249430 |
BOEC, normal 6 |
| GSM249431 |
BOEC, normal 7 |
| GSM249432 |
BOEC, normal 8 |
| GSM249433 |
BOEC, normal 9 |
| GSM249434 |
BOEC, normal 10 |
| GSM249435 |
BOEC, normal 11 |
| GSM249436 |
BOEC, normal 12 |
| GSM249437 |
BOEC, normal 13 |
| GSM249438 |
BOEC, normal 14 |
| GSM249439 |
BOEC, normal 15 |
| GSM249440 |
BOEC, normal 16 |
| GSM249441 |
BOEC, normal 17 |
| GSM249442 |
BOEC, normal 18 |
| GSM249443 |
BOEC, normal 19 |
| GSM249444 |
BOEC, normal 20 |
| GSM249445 |
BOEC, normal 21 |
| GSM249446 |
BOEC, normal 22 |
| GSM249447 |
BOEC, normal 23 |
| GSM249448 |
BOEC, normal 24 |
| GSM249449 |
BOEC, normal 25 |
| GSM249450 |
BOEC, normal 26 |
| GSM249451 |
BOEC, normal 27 |
| GSM427263 |
BOEC, VT sample 1 |
| GSM427264 |
BOEC, VT sample 2 |
| GSM427265 |
BOEC, VT sample 3 |
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| Relations |
| BioProject |
PRJNA119805 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE17078_RAW.tar |
101.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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