|
| Status |
Public on Nov 23, 2022 |
| Title |
ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization
|
| |
|
| Overall design |
RNA-seq of rescue experiment in ITGB4-hi cells with knockout of p63/p73 (double KO, dKO). dKO cells were engineered to ectopically express a control empty vector (EV), dNp63, TAp73, or both dNp63/TAp73 (dual). ITGB4-lo cells were engineered to express a control empty vector (EV) or dNp63. RNA-seq was performed on biolgical duplicates.
|
| Web link |
https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00815-2
|
| |
|
| Contributor(s) |
r Lambert A, Weinberg R, Yuan B |
| Citation(s) |
36538894 |
| |
| Submission date |
Apr 07, 2021 |
| Last update date |
Mar 10, 2023 |
| Contact name |
Arthur W. Lambert |
| Organization name |
Whitehead Institute
|
| Lab |
Robert A. Weinberg
|
| Street address |
455 Main street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE172407 |
p63/p73 maintain cancer stem cells in a quasi-mesenchymal state and drive metastatic colonization via EGFR signaling |
|
| Relations |
| BioProject |
PRJNA720333 |
| SRA |
SRP313800 |
Less...
More...