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Series GSE171653 Query DataSets for GSE171653
Status Public on Jun 30, 2023
Title Bromocriptine reduces endometrial cell growth in women with adenomyosis by targeting glucose metabolism
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary The primary aim of this study is to study the molecular changes in the endometrium of women with diffuse adenomyosis at baseline and after treatment with six months of vaginal bromocriptine, as a secondary outcome of a clinical trial.  Pictorial Blood Loss Assessment Chart (PBLAC) was used to assess the amount of menstrual bleeding. The results suggest an anti-proliferative effect of bromocriptine in the endometrium in women with adenomyosis achieved by regulating genes associated with glucose metabolism. We speculate that the above mechanism could explain the reduced bleeding and pain observed in women with adenomyosis after bromocriptine treatment. 
 
Overall design The current study is a single arm, pre-post intervention study in a University-hospital initiated clinical trial.
Twelve women diagnosed with diffuse adenomyosis were administered for six months with a daily dose of 5mg vaginal bromocriptine.
Endometrial biopsies were collected at baseline and at the end of treatment.
 
Contributor(s) Bogavarappu NR
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Apr 07, 2021
Last update date Jun 30, 2023
Contact name Nageswara Rao Boggavarapu
E-mail(s) nagsdsh@gmail.com
Organization name Karolinska Institutet
Department Women and Children health
Lab Bioclinicum J9:30
Street address Visionsgatan 4
City Solna
State/province stockholm
ZIP/Postal code 17164
Country Sweden
 
Platforms (1)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (48)
GSM5229771 AB1_Subject 1 adenomyosis baseline [RNA_seq]
GSM5229772 AB2_Subject 2 adenomyosis baseline [RNA_seq]
GSM5229773 AB3_Subject 3 adenomyosis baseline [RNA_seq]
Relations
BioProject PRJNA720415
SRA SRP313859

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE171653_mRNA_Raw_expression.txt.gz 2.1 Mb (ftp)(http) TXT
GSE171653_mRNA_processed-file.txt.gz 142.0 Kb (ftp)(http) TXT
GSE171653_miRNA_Raw_expression.txt.gz 905.7 Kb (ftp)(http) TXT
GSE171653_miRNA_processed.txt.gz 43.8 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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