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| Status |
Public on Jul 14, 2021 |
| Title |
Transcriptional Changes Associated with Acute to Chronic Stage Muscle Adaptations in a Model of Rotator Cuff Tendon Tear |
| Organism |
Oryctolagus cuniculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we collected rabbit supraspinatus muscle tissue with higher temporal resolution (1, 2, 4, 8, 16 weeks) post-tenotomy (n=6/group), where muscle degeneration occurs at later time points, to determine if transcriptional changes occur. RNA sequencing and analyses were performed using standard techniques to identify a transcriptional timeline of rotator cuff muscle changes and related morphological sequelae.
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| Overall design |
rotator cuff muscle mRNA after tenotomy injury at 1, 2, 4, 8, 16 weeks post-tenotomy
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| Contributor(s) |
Vasquez-Bolanos LS, Gibbons MC, Ruoss S, Wu IT, Hyman SA, Vargas-Vila M, Esparza MC, Fithian DC, Singh A, Nasamran CA, Fisch K, Ward SR |
| Citation(s) |
34421646 |
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| Submission date |
Apr 23, 2021 |
| Last update date |
Aug 24, 2021 |
| Contact name |
Samuel Richard Ward |
| E-mail(s) |
srward@ucsd.edu
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| Phone |
8585344918
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| Organization name |
University of California San Diego
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| Department |
Orthopaedic Surgery, Radiology, and Bioengineering
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| Lab |
Muscle Physiology
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| Street address |
9500 Gilman Drive (0863)
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
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| Platforms (1) |
| GPL25392 |
Illumina HiSeq 4000 (Oryctolagus cuniculus) |
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| Samples (58)
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| Relations |
| BioProject |
PRJNA724734 |
| SRA |
SRP316121 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173234_rawcounts_NH_ward.xlsx |
6.5 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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