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| Status |
Public on May 07, 2021 |
| Title |
An integrated transcriptomic approach to identify molecular markers of calcineurin inhibitor nephrotoxicity in pediatric kidney transplant recipients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Calcineurin inhibitor nephrotoxicity (CNIT) has been associated with the development of chronic renal allograft dysfunction and decreased graft survival. This study evaluated 37 formalin-fixed paraffin-embedded biopsies from pediatric kidney transplant recipients using gene expression profiling.
Oxidative phosphorylation and mitochondrial dysfunction were the top molecular pathways as-sociated with overexpressed genes in CNIT samples. Decreased ATP synthesis was identified as a significant biological function in CNIT, while key toxicology pathways included NRF2-mediated oxidative stress response and increased permeability transition of mitochondria.
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| |
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| Overall design |
To identify a unique molecular signature for accurate pediatric CNIT diagnosis.
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| |
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| Contributor(s) |
Mas V, Dumur CI, Maluf D |
| Citation(s) |
34063776 |
| Submission date |
May 06, 2021 |
| Last update date |
Jun 28, 2021 |
| Contact name |
Catherine Dumur |
| Organization name |
Sonic Healthcare USA
|
| Department |
Anatomic Pathology
|
| Lab |
Bernhardt
|
| Street address |
5008 Mustang Rd
|
| City |
Jacksonville |
| State/province |
FL |
| ZIP/Postal code |
32216 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (37)
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| Relations |
| BioProject |
PRJNA728193 |
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