|
| Status |
Public on Oct 26, 2021 |
| Title |
Chromatin accessibility of TGFβ target genes determines the efficiency of hemogenic endothelial specification by RUNX1 |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
Epigenome and transcriptome characterization of endothelial cells following RUNX1 overexpression.
|
| |
|
| Overall design |
Examination of transcriptome, chromatin accessibility, and histone modifications in endothelial cells subjected to overexpression of RUNX1 at different developmental timepoints.
|
| |
|
| Contributor(s) |
Howell ED, Gao P, Tan K, Speck NA |
| Citation(s) |
34675061 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL091724 |
Biochemistry of Leukemia Virus Core-Binding Factor |
UNIVERSITY OF PENNSYLVANIA |
NANCY SPECK |
| R01 HD089245 |
Mechanisms of endothelial-to-hemogenic transition mediated by Runx1 |
CHILDREN'S HOSPITAL OF PHILADELPHIA |
NANCY SPECK |
| R01 HD089245 |
Mechanisms of endothelial-to-hemogenic transition mediated by Runx1 |
CHILDREN'S HOSPITAL OF PHILADELPHIA |
Kai Tan |
| F31 HL150952 |
Identifying necessary chromatin states and targets for hemogenic specification and reprogramming |
UNIVERSITY OF PENNSYLVANIA |
Elizabeth Howell |
| F31 HL120615 |
Ectopic Runx1 expression in non-hemogenic endothelium induces blood formation |
UNIVERSITY OF PENNSYLVANIA |
Amanda Danielle Phillips |
|
| |
| Submission date |
May 17, 2021 |
| Last update date |
Oct 26, 2021 |
| Contact name |
Kai Tan |
| E-mail(s) |
tank1@chop.edu
|
| Organization name |
Children's Hospital of Philadelphia
|
| Street address |
3501 CIVIC CENTER BLVD
|
| City |
PHILADELPHIA |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (33)
|
|
| Relations |
| BioProject |
PRJNA730589 |
| SRA |
SRP320203 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE174591_E13_1Runx1_ATAC.bw |
446.9 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_1Runx1_ATAC_peaks.bed.gz |
2.3 Mb |
(ftp)(http) |
BED |
| GSE174591_E13_1Runx1_RNA.bw |
51.3 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_2Runx1_ATAC.bw |
359.9 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_2Runx1_ATAC_peaks.bed.gz |
1.9 Mb |
(ftp)(http) |
BED |
| GSE174591_E13_2Runx1_K4me1_IN.bw |
686.0 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_2Runx1_K4me1_IP.bw |
526.5 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_2Runx1_K4me1_IP_peaks.bed.gz |
2.1 Mb |
(ftp)(http) |
BED |
| GSE174591_E13_2Runx1_RNA.bw |
72.9 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_Ctrl_ATAC.bw |
517.0 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_Ctrl_ATAC_peaks.bed.gz |
2.3 Mb |
(ftp)(http) |
BED |
| GSE174591_E13_Ctrl_K4me1_IN.bw |
623.3 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_Ctrl_K4me1_IP.bw |
777.7 Mb |
(ftp)(http) |
BW |
| GSE174591_E13_Ctrl_K4me1_IP_peaks.bed.gz |
1.1 Mb |
(ftp)(http) |
BED |
| GSE174591_E13_Ctrl_RNA.bw |
58.0 Mb |
(ftp)(http) |
BW |
| GSE174591_E9_1Runx1_ATAC.bw |
486.4 Mb |
(ftp)(http) |
BW |
| GSE174591_E9_1Runx1_ATAC_peaks.bed.gz |
2.3 Mb |
(ftp)(http) |
BED |
| GSE174591_E9_1Runx1_RNA.bw |
71.8 Mb |
(ftp)(http) |
BW |
| GSE174591_E9_Ctrl_ATAC.bw |
589.3 Mb |
(ftp)(http) |
BW |
| GSE174591_E9_Ctrl_ATAC_peaks.bed.gz |
2.3 Mb |
(ftp)(http) |
BED |
| GSE174591_E9_Ctrl_RNA.bw |
76.5 Mb |
(ftp)(http) |
BW |
| GSE174591_Liver_2Runx1_ATAC.bw |
148.0 Mb |
(ftp)(http) |
BW |
| GSE174591_Liver_2Runx1_ATAC_peaks.bed.gz |
946.0 Kb |
(ftp)(http) |
BED |
| GSE174591_Liver_2Runx1_RNA.bw |
63.3 Mb |
(ftp)(http) |
BW |
| GSE174591_Liver_Ctrl_ATAC.bw |
244.1 Mb |
(ftp)(http) |
BW |
| GSE174591_Liver_Ctrl_ATAC_peaks.bed.gz |
957.3 Kb |
(ftp)(http) |
BED |
| GSE174591_Liver_Ctrl_RNA.bw |
68.4 Mb |
(ftp)(http) |
BW |
| GSE174591_RPKM_norm.txt.gz |
2.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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