|
| Status |
Public on May 10, 2022 |
| Title |
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the potential role of COVID-19 severity associated GWAS hits affecting the cis-regulatory architecure of human immune cell types. We used high-resolution chromatin conformation capture and accessibility to identify potential effector genes
|
| |
|
| Overall design |
We performed ATAC-seq, RNA-seq, and Promoter Focused Capture C on Naïve B and GCB cells
|
| |
|
| Contributor(s) |
Pahl MC, Romberg N, Grant SF, Wells AD |
| Citation(s) |
35659055, 38562830 |
| Submission date |
May 18, 2021 |
| Last update date |
Apr 17, 2024 |
| Contact name |
Matthew C Pahl |
| E-mail(s) |
pahlm@email.chop.edu
|
| Phone |
5704282303
|
| Organization name |
Children's Hospital of Philadelphia
|
| Department |
Center for Spatial and Functional Genomics
|
| Lab |
Struan Grant and Andrew Wells
|
| Street address |
3615 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (8)
|
| GSM5321863 |
Germinal Center B cell Donor 180 (RNA-seq) |
| GSM5321864 |
Germinal Center B cell Donor 181 (RNA-seq) |
| GSM5321865 |
Germinal Center B cell Donor 184 (RNA-seq) |
|
| This SubSeries is part of SuperSeries: |
| GSE174658 |
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types |
|
| Relations |
| BioProject |
PRJNA730906 |
| SRA |
SRP320385 |
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