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Series GSE175764 Query DataSets for GSE175764
Status Public on Apr 06, 2022
Title RNA-sequencing transcriptional profile of human hearts [HumanHeartFailure]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Organ fibroblasts are essential components of homeostatic and diseased tissues, as they participate in sensing the microenvironment and communicating with other resident cells. They are also involved in pathological remodeling and fibrosis, caused by excessive deposition of connective tissue after injury, which impairs organ function. It is estimated that 45% of deaths in developed countries are linked to chronic fibrosis, yet current drugs on the market are both inefficient and non-specific to this condition. We have previously shown that cardiac fibroblasts display a unique cardiogenic identity, important for cardiac pathological remodeling. To determine whether fibroblasts from other organ systems display a molecular signature unique to their organ of origin, we characterized fibroblasts isolated from the adult mouse skin, lung, kidney, gonad and liver, and documented a molecular positional and organ signature that is likely a remnant from embryonic development. This information opens novel opportunities for the treatment of fibrotic diseases in a more precise, organ-specific manner.
 
Overall design RNA-sequencing transcriptional profile of human hearts, including heart failure and healthy control. Samples were obtained from n=5 healthy individuals and n=5 individuals with heart failure.
 
Contributor(s) Forte E, Ramialison M, Nim HT, Furtado MB
Citation(s) 35293863
Submission date May 28, 2021
Last update date Apr 06, 2022
Contact name Hieu Tri Nim
E-mail(s) hieu.nim@monash.edu
Phone 0478367105
Organization name Monash University
Department Australian Regenerative Medicine Institute
Street address Monash University Clayton Campus, Wellington Rd
City Clayton
State/province VIC
ZIP/Postal code 3800
Country Australia
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (10)
GSM5346050 Heart failure [2-044LV]
GSM5346051 Heart failure [2-048LV]
GSM5346052 Heart failure [3-149LV]
This SubSeries is part of SuperSeries:
GSE175765 RNA-sequencing transcriptional profile of kidney capsule derived organ fibroblasts from adult mice, CRISPR-knockdown organ fibroblasts from adult mice, and human hearts
Relations
BioProject PRJNA733500
SRA SRP321809

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE175764_Milena_Furtado_011718_HEART_FAILURE_vs_CONTROL-FINAL-counts.txt.gz 1.0 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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